Trends in inpatient antiparkinson drug use in the USA, 2001–2012
Identifieur interne : 000483 ( Main/Exploration ); précédent : 000482; suivant : 000484Trends in inpatient antiparkinson drug use in the USA, 2001–2012
Auteurs : James A. G. Crispo [États-Unis] ; Yannick Fortin ; Dylan P. Thibault [États-Unis] ; Matthew Emons [États-Unis] ; Lise M. Bjerre ; Dafna E. Kohen ; Santiago Perez-Lloret [Argentine] ; Donald Mattison ; Allison W. Willis [États-Unis] ; Daniel KrewskiSource :
- European Journal of Clinical Pharmacology [ 0031-6970 ] ; 2015.
Descripteurs français
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Catechol O-Methyltransferase Inhibitors (therapeutic use), Cholinergic Antagonists (therapeutic use), Dopamine Agonists (therapeutic use), Drug Utilization (trends), Female, Humans, Inpatients (statistics & numerical data), Levodopa (therapeutic use), Male, Middle Aged, Monoamine Oxidase Inhibitors (therapeutic use), Parkinson Disease (drug therapy), Practice Patterns, Physicians' (trends), United States.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Catechol O-Methyltransferase Inhibitors, Cholinergic Antagonists, Dopamine Agonists, Levodopa, Monoamine Oxidase Inhibitors.
- geographic : United States.
- drug therapy : Parkinson Disease.
- statistics & numerical data : Inpatients.
- trends : Drug Utilization, Practice Patterns, Physicians'.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.
Abstract
Although therapeutic options and clinical guidelines for Parkinson’s disease (PD) have changed significantly in the past 15 years, prescribing trends in the USA remain unknown. The purpose of this population-based cohort study was to examine patterns of inpatient antiparkinson drug use between January 2001 and December 2012 in relation to clinical guideline publication, drug introduction/withdrawal, and emerging safety concerns.
A total of 16,785 inpatients receiving pharmacological treatment for PD were identified in the Cerner Health Facts database. Our primary outcome was standardized (age, sex, race, and census region) annual prevalence of antiparkinson drug use. We also examined antiparkinson medication trends and polypharmacy by age and sex.
The most frequently prescribed antiparkinson drugs between 2001 and 2012 were levodopa (85 %) and dopamine agonists (28 %). Dopamine agonist use began declining in 2007, from 34 to 27 % in 2012. The decline followed publication of the American Academy of Neurology’s practice parameter refuting levodopa toxicity, pergolide withdrawal, and pramipexole label revisions. Despite safety concerns for cognitive impairment and falls, individuals ≥80 years of age demonstrated stable rates of dopamine agonist use from 2001 to 2012. Polypharmacy was most common in younger patients.
Dopamine agonist use declined from 2007 to 2012, suggesting that increased awareness of safety issues and practice guidelines influenced prescribing. These events appear to have minimally influenced treatment provided to older PD patients. Antiparkinson prescribing trends indicate that safety and best practice information may be communicated effectively.
The online version of this article (doi:10.1007/s00228-015-1881-4) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s00228-015-1881-4
PubMed: 26081062
PubMed Central: 4500853
Affiliations:
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G." last="Crispo">James A. G. Crispo</name><affiliation><nlm:aff id="Aff1">McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2">Fulbright Canada Student, University of Pennsylvania, Philadelphia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Fulbright Canada Student, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Fortin, Yannick" sort="Fortin, Yannick" uniqKey="Fortin Y" first="Yannick" last="Fortin">Yannick Fortin</name><affiliation><nlm:aff id="Aff1">McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation></author><author><name sortKey="Thibault, Dylan P" sort="Thibault, Dylan P" uniqKey="Thibault D" first="Dylan P." last="Thibault">Dylan P. Thibault</name><affiliation wicri:level="2"><nlm:aff id="Aff3">Departments of Neurology and Biostatistics & Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Neurology and Biostatistics & Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Emons, Matthew" sort="Emons, Matthew" uniqKey="Emons M" first="Matthew" last="Emons">Matthew Emons</name><affiliation wicri:level="2"><nlm:aff id="Aff4">Cerner Corporation, Culver, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Cerner Corporation, Culver</wicri:cityArea></affiliation></author><author><name sortKey="Bjerre, Lise M" sort="Bjerre, Lise M" uniqKey="Bjerre L" first="Lise M." last="Bjerre">Lise M. Bjerre</name><affiliation><nlm:aff id="Aff5">C.T. Lamont Primary Health Care Research Centre, Department of Family Medicine, University of Ottawa, Ottawa, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff6">Bruyère Research Institute, Ottawa, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff7">School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation></author><author><name sortKey="Kohen, Dafna E" sort="Kohen, Dafna E" uniqKey="Kohen D" first="Dafna E." last="Kohen">Dafna E. Kohen</name><affiliation><nlm:aff id="Aff7">School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation></author><author><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Clinical Pharmacology and Epidemiology, Catholic University, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Clinical Pharmacology and Epidemiology, Catholic University, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Mattison, Donald" sort="Mattison, Donald" uniqKey="Mattison D" first="Donald" last="Mattison">Donald Mattison</name><affiliation><nlm:aff id="Aff1">McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff9">Risk Sciences International, Ottawa, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation></author><author><name sortKey="Willis, Allison W" sort="Willis, Allison W" uniqKey="Willis A" first="Allison W." last="Willis">Allison W. Willis</name><affiliation wicri:level="2"><nlm:aff id="Aff3">Departments of Neurology and Biostatistics & Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Neurology and Biostatistics & Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Krewski, Daniel" sort="Krewski, Daniel" uniqKey="Krewski D" first="Daniel" last="Krewski">Daniel Krewski</name><affiliation><nlm:aff id="Aff1">McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">European Journal of Clinical Pharmacology</title><idno type="ISSN">0031-6970</idno><idno type="eISSN">1432-1041</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (therapeutic use)</term><term>Catechol O-Methyltransferase Inhibitors (therapeutic use)</term><term>Cholinergic Antagonists (therapeutic use)</term><term>Dopamine Agonists (therapeutic use)</term><term>Drug Utilization (trends)</term><term>Female</term><term>Humans</term><term>Inpatients (statistics & numerical data)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Monoamine Oxidase Inhibitors (therapeutic use)</term><term>Parkinson Disease (drug therapy)</term><term>Practice Patterns, Physicians' (trends)</term><term>United States</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Catechol O-Methyltransferase Inhibitors</term><term>Cholinergic Antagonists</term><term>Dopamine Agonists</term><term>Levodopa</term><term>Monoamine Oxidase Inhibitors</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Inpatients</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Drug Utilization</term><term>Practice Patterns, Physicians'</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Although therapeutic options and clinical guidelines for Parkinson’s disease (PD) have changed significantly in the past 15 years, prescribing trends in the USA remain unknown. The purpose of this population-based cohort study was to examine patterns of inpatient antiparkinson drug use between January 2001 and December 2012 in relation to clinical guideline publication, drug introduction/withdrawal, and emerging safety concerns.</p></sec><sec><title>Methods</title><p>A total of 16,785 inpatients receiving pharmacological treatment for PD were identified in the Cerner Health Facts database. Our primary outcome was standardized (age, sex, race, and census region) annual prevalence of antiparkinson drug use. We also examined antiparkinson medication trends and polypharmacy by age and sex.</p></sec><sec><title>Results</title><p>The most frequently prescribed antiparkinson drugs between 2001 and 2012 were levodopa (85 %) and dopamine agonists (28 %). Dopamine agonist use began declining in 2007, from 34 to 27 % in 2012. The decline followed publication of the American Academy of Neurology’s practice parameter refuting levodopa toxicity, pergolide withdrawal, and pramipexole label revisions. Despite safety concerns for cognitive impairment and falls, individuals ≥80 years of age demonstrated stable rates of dopamine agonist use from 2001 to 2012. Polypharmacy was most common in younger patients.</p></sec><sec><title>Conclusions</title><p>Dopamine agonist use declined from 2007 to 2012, suggesting that increased awareness of safety issues and practice guidelines influenced prescribing. These events appear to have minimally influenced treatment provided to older PD patients. Antiparkinson prescribing trends indicate that safety and best practice information may be communicated effectively.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s00228-015-1881-4) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Callesen, Mb" uniqKey="Callesen M">MB Callesen</name></author><author><name sortKey="Scheel Kruger, J" uniqKey="Scheel Kruger J">J Scheel-Kruger</name></author><author><name sortKey="Kringelbach, Ml" uniqKey="Kringelbach M">ML Kringelbach</name></author><author><name sortKey="Moller, A" uniqKey="Moller A">A Moller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weintraub, D" uniqKey="Weintraub D">D Weintraub</name></author><author><name sortKey="Nirenberg, Mj" uniqKey="Nirenberg M">MJ 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Crespi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Argentine</li><li>États-Unis</li></country><region><li>Californie</li><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Bjerre, Lise M" sort="Bjerre, Lise M" uniqKey="Bjerre L" first="Lise M." last="Bjerre">Lise M. Bjerre</name><name sortKey="Fortin, Yannick" sort="Fortin, Yannick" uniqKey="Fortin Y" first="Yannick" last="Fortin">Yannick Fortin</name><name sortKey="Kohen, Dafna E" sort="Kohen, Dafna E" uniqKey="Kohen D" first="Dafna E." last="Kohen">Dafna E. Kohen</name><name sortKey="Krewski, Daniel" sort="Krewski, Daniel" uniqKey="Krewski D" first="Daniel" last="Krewski">Daniel Krewski</name><name sortKey="Mattison, Donald" sort="Mattison, Donald" uniqKey="Mattison D" first="Donald" last="Mattison">Donald Mattison</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Crispo, James A G" sort="Crispo, James A G" uniqKey="Crispo J" first="James A. G." last="Crispo">James A. G. Crispo</name></region><name sortKey="Emons, Matthew" sort="Emons, Matthew" uniqKey="Emons M" first="Matthew" last="Emons">Matthew Emons</name><name sortKey="Thibault, Dylan P" sort="Thibault, Dylan P" uniqKey="Thibault D" first="Dylan P." last="Thibault">Dylan P. Thibault</name><name sortKey="Willis, Allison W" sort="Willis, Allison W" uniqKey="Willis A" first="Allison W." last="Willis">Allison W. Willis</name></country><country name="Argentine"><noRegion><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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